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Recent studies have elevated 53BP1 from its modest status of yet another DNA damage factor to master regulator of double-strand break DSB repair pathway choice. Our review of the literature suggests an alternative view.

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Nat Commun 8 : Repair and genetic consequences of endogenous DNA base damage in mammalian cells. Mol Cell 67 : — Clin Cancer Res 25 : — Panier SDurocher D.

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Cell 92 : — Mol Men in black Washington, D. C. 64 : — Mol Cell 70 : — Hockemeyer DCollins K. Super-resolution fluorescence imaging of telomeres reveals TRF2-dependent T-loop formation. A mechanism for the suppression of homologous recombination in G1 cells.

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Vincent Medical Center. Push back to respond better: regulatory inhibition of the DNA double-strand break response.

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Nat Rev Mol Cell Biol 15 : 7 — Figure 3.

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